In the 28th century, Valerian and Laureline are special operatives charged with keeping order throughout the human territories. On assignment from the Minister of Defense, the two undertake a mission to Alpha, an ever-expanding metropolis where species from across the universe have converged over centuries to share knowledge, intelligence, and cultures. At the center of Alpha is a mysterious dark force which threatens the peaceful existence of the City of a Thousand Planets, and Valerian and Laureline must race to identify the menace and safeguard not just Alpha, but the future of the universe.
There exists an ancient manuscript still writing itself called the Lexicon. It supposedly tells of the coming of the Anti-Christ, and happens to fall into the hands of an unsuspecting woman. Now, she is being pursued by angels intent on obtaining the information from the book.